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Article

Role of CD4 Receptor Down-regulation During HIV-1 Infection

1 Jan 2004

Abstract excerpt

Human immunodeficiency virus has evolved several redundant mechanisms to remove its receptor, the CD4 molecule, from the cell surface. Indeed, HIV-1 encodes three proteins, Nef, Vpu and Env, that have a profound effect on CD4 trafficking and catabolism. Given this functional convergence, it is believed that cell surface CD4 regulation constitutes an important determinant of viral replication and pathogenesis in...

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PMID: 15053340
DOI: 10.2174/1570162043485086

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