Article
Induction by human immunodeficiency viruses types 1 and 2 of degradation of CD4 but not of a CD4 mutant unable to bind viral envelope glycoproteins.
Journal of acquired immune deficiency syndromes and human retrovirology : official publication of the International Retrovirology Association - 15 Apr 1995
Cucchiarini M, Cagnon L, Giordanengo V, Doglio A, Lefebvre J C
Abstract excerpt
HIV-1 appears to use a multiple gene strategy to regulate CD4 receptor expression, which emphasizes the importance of this regulation in the viral life cycle. The cytoplasmic interaction between gp160 and CD4 is probably the major event governing CD4 down-regulation, although other viral proteins...
Topics
- Base Sequence
- Blotting, Western
- CD4 Antigens
- Cell Line
- DNA Primers
- Down-Regulation
- Enzyme-Linked Immunosorbent Assay
- Gene Expression Regulation, Viral
- Gene Products, env
- Gene Products, nef
- HIV Envelope Protein gp120
- HIV Envelope Protein gp160
- HIV-1