Article
Experimental hemochromatosis due to MHC class I HFE deficiency: immune status and iron metabolism.
Proceedings of the National Academy of Sciences of the United States of America - 9 Nov 1999
Bahram S, Gilfillan S, Kühn L C, Moret R, Schulze J B, Lebeau A, Schümann K
Abstract excerpt
The puzzling linkage between genetic hemochromatosis and histocompatibility loci became even more so when the gene involved, HFE, was identified. Indeed, within the well defined, mainly peptide-binding, MHC class I family of molecules, HFE seems to perform an unusual yet essential function. As yet, our understanding of HFE function in iron homeostasis is only partial; an even more open question is its possible...
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