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Article

The major histocompatibility complex-encoded HFE in iron homeostasis and immune function.

Immunologic research - 1 Jan 2000

Salter-Cid L, Peterson P A, Yang Y

Abstract excerpt

HFE is a non-classical major histocompatibility complex class I molecule that complexes with a beta2-microglobulin. A functional link between HFE and iron metabolism has been established by the discovery of a physical association between HFE and the transferrin receptor. By inhibiting transferrin receptor internalization, HFE functions as a negative modulator of transferrin receptor function. In addition, HFE...

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Source

Identifiers

PMID: 10945226
DOI: 10.1385/IR:22:1:43

Genes

HFE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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