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Article

HFE, the MHC and hemochromatosis: paradigm for an extended function for MHC class I.

Tissue antigens - 1 Apr 2003

Cardoso C S, de Sousa M

Abstract excerpt

HFE was discovered as the hereditary hemochromatosis (HH) gene. It is located on chromosome 6 (6p21.3), 4Mb telomeric to the HLA-A locus, and its product has a structure similar to MHC class I molecules. HFE encodes two frequent mutations: C282Y and H63D. One of these (C282Y) is present in a large proportion of Caucasian HH patients. HFE has a tissue distribution compatible with a role in iron absorption...

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Source

Identifiers

PMID: 12753664
DOI: 10.1034/j.1399-0039.2003.00065.x

Genes

HFE

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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