Article
Human dendritic cells express the thrombopoietin receptor, c-Mpl.
British journal of haematology - 1 Jun 1999
Kumamoto T, Azuma E, Tanaka M, Qi J, Hirayama M, Zhang S L, Kobayashi M, Iwamoto S, Komada Y, Yamamoto H, Nakashima K, Sakurai M
Abstract excerpt
Human thrombopoietin (TPO) is a haemopoietic growth factor that is essential for the growth and development of megakaryocytes. However, c-Mpl, the TPO receptor, has been detected in human leukaemic cell lines with a myelomonocytic phenotype. These results raise the possibility that dendritic cells (DC), a putative myeloid lineage cell, may also express c-Mpl and respond to TPO. In haemopoietic stem cell...
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