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Article

Human thrombopoietin: gene structure, cDNA sequence, expression, and chromosomal localization.

20 Dec 1994

Abstract excerpt

Thrombopoietin (TPO), a lineage-specific cytokine affecting the proliferation and maturation of megakaryocytes from committed progenitor cells, is believed to be the major physiological regulator of circulating platelet levels. Recently we have isolated a cDNA encoding a ligand for the murine c-mpl protooncogene and shown it to be TPO. By employing a murine cDNA probe, we have isolated a gene encoding human TPO...

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Identifiers

PMID: 7809166
DOI: 10.1073/pnas.91.26.13023

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