Article
Efficient presentation of soluble antigen by cultured human dendritic cells is maintained by granulocyte/macrophage colony-stimulating factor plus interleukin 4 and downregulated by tumor necrosis factor alpha.
The Journal of experimental medicine - 1 Apr 1994
Sallusto F, Lanzavecchia A
Abstract excerpt
Using granulocyte/macrophage colony-stimulating factor (GM-CSF) and interleukin 4 we have established dendritic cell (DC) lines from blood mononuclear cells that maintain the antigen capturing and processing capacity characteristic of immature dendritic cells in vivo. These cells have typical den...
Topics
- Antigen-Antibody Complex
- Antigens
- B-Lymphocytes
- Cell Differentiation
- Cells, Cultured
- Dendritic Cells
- Down-Regulation
- Granulocyte-Macrophage Colony-Stimulating Factor
- Humans
- Interleukin-4
- Phenotype
- Receptors, IgG
- Solubility
- Tumor Necrosis Factor-alpha