Article
Development of dendritic cells in culture from human and murine thymic precursor cells.
Cellular and molecular biology (Noisy-le-Grand, France) - 1 Feb 2001
Kelly K A, Lucas K, Hochrein H, Metcalf D, Wu L, Shortman K
Abstract excerpt
The earliest T-precursor population in the adult murine thymus can give rise to dendritic cells (DC) in culture if stimulated with a cocktail of cytokines that includes interleukin (IL)-3, but not with cytokine mixes based on granulocyte-macrophage colony stimulating factor (GM-CSF), normally used to generate myeloid-derived DC. This and other evidence led to the proposal that two different lineages of DC exist,...
Topics
- Animals
- Antigens, CD
- Cell Culture Techniques
- Cell Division
- Cell Membrane
- Cells, Cultured
- Dendritic Cells
- Granulocyte-Macrophage Colony-Stimulating Factor
- Hematopoietic Stem Cells
- Humans
- Infant
- Interleukin-3
- Kinetics
- Lymphocytes
- Mice
- Mice, Inbred C57BL
- Phenotype
- T-Lymphocytes