Human CD14+ leukocytes acquire the phenotype and function of antigen-presenting dendritic cells when cultured in GM-CSF and IL-4.

doi:10.1002/jlb.59.2.208

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Article

Human CD14+ leukocytes acquire the phenotype and function of antigen-presenting dendritic cells when cultured in GM-CSF and IL-4.

Journal of leukocyte biology - 1 Feb 1996

Kiertscher S M, Roth M D

Abstract excerpt

The combination of granulocyte-macrophage colony stimulating factor (GM-CSF) and interleukin-4 (IL-4) induces the growth of antigen-presenting cells (APC) from adherent peripheral blood leukocytes. These cells have been characterized as dendritic cells (DC), yet many questions exist regarding the...

Topics

Antibodies
Antigen Presentation
Antigens, CD
B7-2 Antigen
Cell Adhesion
Cells, Cultured
Dendritic Cells
Flow Cytometry
Granulocyte-Macrophage Colony-Stimulating Factor
HLA-DR Antigens
Hematopoietic Stem Cells
Humans
Immunomagnetic Separation
Leukocytes
Lipopolysaccharide Receptors
Macrophages
Membrane Glycoproteins
Phenotype

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Open in PubMed

Identifiers

PMID: 8603993
DOI: 10.1002/jlb.59.2.208

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8603993-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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