Article
A catalytically active Jak2 is required for the angiotensin II-dependent activation of Fyn.
The Journal of biological chemistry - 12 Nov 1999
Sayeski P P, Ali M S, Safavi A, Lyles M, Kim S O, Frank S J, Bernstein K E
Abstract excerpt
Recent work with interleukins has shown a convergence of tyrosine phosphorylation signal transduction cascades at the level of the Janus and Src families of tyrosine kinases. Here we demonstrate that activation of the seven-transmembrane AT(1) receptor by angiotensin II induces a physical association between Jak2 and Fyn, in vivo. This association requires the catalytic activity of Jak2 but not Fyn. Deletion...
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