Article
The JAK-binding protein JAB inhibits Janus tyrosine kinase activity through binding in the activation loop.
The EMBO journal - 1 Mar 1999
Yasukawa H, Misawa H, Sakamoto H, Masuhara M, Sasaki A, Wakioka T, Ohtsuka S, Imaizumi T, Matsuda T, Ihle J N, Yoshimura A
Abstract excerpt
The Janus family of protein tyrosine kinases (JAKs) regulate cellular processes involved in cell growth, differentiation and transformation through their association with cytokine receptors. However, compared with other kinases, little is known about cellular regulators of the JAKs. We have recen...
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