Article
Prenatal origin of acute lymphoblastic leukaemia in children.
Lancet (London, England) - 30 Oct 1999
Wiemels J L, Cazzaniga G, Daniotti M, Eden O B, Addison G M, Masera G, Saha V, Biondi A, Greaves M F
Abstract excerpt
BACKGROUND: There is little current insight into the natural history of childhood leukaemia or the timing of relevant mutational events. TEL-AML1 gene fusion due to chromosomal translocation is frequently seen in the common form of childhood acute lymphoblastic leukaemia. We investigated whether this abnormality arises prenatally. METHODS: We identified, by reverse-transcriptase PCR screening of blood or bone...
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