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In utero origin of t(8;21) AML1-ETO translocations in childhood acute myeloid leukemia

15 May 2002

Abstract excerpt

Recent reports have established the prenatal origin of leukemia translocations and resultant fusion genes in some patients, including MLL-AF4 translocations in infants and TEL-AML1 translocations in children. We now report evidence for the prenatal origin of a translocation in childhood acute myeloid leukemia (AML). The t(8;21) AML1-ETO translocations were sequenced at the genomic level in 10 diagnostic leukemia...

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Identifiers

PMID: 11986239
DOI: 10.1182/blood.v99.10.3801

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