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Backtracking leukemia to birth: Identification of clonotypic gene fusion sequences in neonatal blood spots

9 Dec 1997

Abstract excerpt

Epidemiological evidence has suggested that some pediatric leukemias may be initiated in utero and, for some pairs of identical twins with concordant leukemia, this possibility has been strongly endorsed by molecular studies of clonality. Direct evidence for a prenatal origin can only be derived by prospective or retrospective detection of leukemia-specific molecular abnormalities in fetal or newborn samples. We...

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PMID: 9391133
DOI: 10.1073/pnas.94.25.13950

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