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Prenatal origin of TEL‐AML1–positive acute lymphoblastic leukemia in children born in California

17 Mar 2003

Abstract excerpt

Acute lymphoblastic leukemia (ALL) is the most common form of childhood cancer. The peak incidence of ALL between ages 2 and 5 is accounted for by one subtype, referred to as common acute lymphoblastic leukemia (cALL). About 25% of cALL patients have the TEL-AML1 gene fusion derived from the t(12;21) chromosomal translocation. Recent evidence from retrospective analysis of neonatal blood spots (Guthrie cards) in...

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PMID: 12661004
DOI: 10.1002/gcc.10199

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