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<b> <i>TEL</i> </b> Deletion Analysis Supports a Novel View of Relapse in Childhood Acute Lymphoblastic Leukemia

15 Aug 2004

Abstract excerpt

PURPOSE: TEL (ETV6)-AML1 (RUNX1) chimeric gene fusions are frequent genetic abnormalities in childhood acute lymphoblastic leukemia (ALL). They often arise prenatally as early events or initiating events and are complemented by secondary postnatal genetic events of which deletion of the non-rearranged, second TEL allele is the most common. This consistent sequence of molecular pathogenesis facilitates an analysis...

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PMID: 15328172
DOI: 10.1158/1078-0432.ccr-04-0584

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