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Article

Increased expression of keratin 16 causes anomalies in cytoarchitecture and keratinization in transgenic mouse skin.

The Journal of cell biology - 1 Oct 1994

Takahashi K, Folmer J, Coulombe P A

Abstract excerpt

Injury to epidermis and other stratified epithelia triggers profound but transient changes in the pattern of keratin expression. In postmitotic cells located at the wound edge, a strong induction of K6, K16, and K17 synthesis occurs at the expense of the keratins produced under the normal situation. The functional significance of these alterations in keratin expression is not known. Here, we report that...

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Identifiers

PMID: 7523421
DOI: 10.1083/jcb.127.2.505
PMCID: PMC2120213

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Increased expression of keratin 16 causes anomalies in cytoarchitecture and keratinization in transgenic mouse skin.PMID 7523421Read ↗

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Directed expression of keratin 16 to the progenitor basal cells of transgenic mouse skin delays skin maturation.Semantic proximity Read ↗

Onset of re-epithelialization after skin injury correlates with a reorganization of keratin filaments in wound edge keratinocytes: defining a potential role for keratin 16.Semantic proximity Read ↗

The Functional Diversity of Epidermal Keratins Revealed by the Partial Rescue of the Keratin 14 Null Phenotype by Keratin 16Semantic proximity Read ↗

Expression of MK6a dominant-negative and C-terminal mutant transgenes in mice has distinct phenotypic consequences in the epidermis and hair follicle.Semantic proximity Read ↗

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In vitro characteristics of early epidermal progenitors isolated from keratin 14 (K14)-deficient mice: Insights into the role of keratin 17 in mouse keratinocytesSemantic proximity Read ↗

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