Differential expression of keratin and keratin associated proteins are linked with hair loss condition in spontaneously mutated inbred mice.

Abstract excerpt

Hair loss condition is heritable and is influenced by multifactorial inheritance. In the present study, spontaneously mutated mice showed hair loss phenotype with defect in the first cycle of hair follicle formation leading to cyclic alopecia. These mutant mice follow autosomal recessive inheritance pattern. The transcriptomic profile and differential gene expression analysis of skin tissues by RNA-sequencing at...

Topics

• Animals
• Alopecia
• Mice
• Mutation
• Hair Follicle
• Keratins
• Gene Expression Profiling
• Transcriptome
• Mice, Mutant Strains