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Article

Overcoming functional redundancy to elicit pachyonychia congenita-like nail lesions in transgenic mice.

Molecular and cellular biology - 1 Jan 2005

Wong Pauline, Domergue Renee, Coulombe Pierre A

Abstract excerpt

Mutations affecting the coding sequence of intermediate filament (IF) proteins account for >30 disorders, including numerous skin bullous diseases, myopathies, neuropathies, and even progeria. The manipulation of IF genes in mice has been widely successful for modeling key features of such clinically distinct disorders. A notable exception is pachyonychia congenita (PC), a disorder in which the nail and other...

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Identifiers

PMID: 15601842
DOI: 10.1128/MCB.25.1.197-205.2005
PMCID: PMC538767

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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