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Article

Constitutive association of BRCA1 and c-Abl and its ATM-dependent disruption after irradiation.

Molecular and cellular biology - 1 Jun 2002

Foray Nicolas, Marot Didier, Randrianarison Voahangy, Venezia Nicole Dalla, Picard Didier, Perricaudet Michel, Favaudon Vincent, Jeggo Penny

Abstract excerpt

BRCA1 plays an important role in mechanisms of response to double-strand breaks, participating in genome surveillance, DNA repair, and cell cycle checkpoint arrests. Here, we identify a constitutive BRCA1-c-Abl complex and provide evidence for a direct interaction between the PXXP motif in the C terminus of BRCA1 and the SH3 domain of c-Abl. Following exposure to ionizing radiation (IR), the BRCA1-c-Abl complex...

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Source

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Identifiers

PMID: 12024016
DOI: 10.1128/MCB.22.12.4020-4032.2002
PMCID: PMC133860

Genes

BRCA1
ATM

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

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