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Article

Multiple factors insulate Msh2-Msh6 mismatch repair activity from defects in Msh2 domain I.

Journal of molecular biology - 26 Aug 2011

Kumar Charanya, Piacente Sarah C, Sibert Justin, Bukata Andrew R, O'Connor Jaime, Alani Eric, Surtees Jennifer A

Abstract excerpt

DNA mismatch repair (MMR) is a highly conserved mutation avoidance mechanism that corrects DNA polymerase misincorporation errors. In initial steps in MMR, Msh2-Msh6 binds mispairs and small insertion/deletion loops, and Msh2-Msh3 binds larger insertion/deletion loops. The msh2Δ1 mutation, which deletes the conserved DNA-binding domain I of Msh2, does not dramatically affect Msh2-Msh6-dependent repair. In...

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Share to Deoxyribonuclease I
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to MutS Homolog 2 Protein

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Source

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Identifiers

PMID: 21726567
DOI: 10.1016/j.jmb.2011.06.030
PMCID: PMC3163898

Genes

MSH3
MSH6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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