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Article

Analysis of beta-catenin gene mutations in pancreatic tumors.

Digestion - 1 Jan 2000

Gerdes B, Ramaswamy A, Simon B, Pietsch T, Bastian D, Kersting M, Moll R, Bartsch D

Abstract excerpt

BACKGROUND/AIM: Mutations of the adenomatous polyposis coli (APC) tumor suppressor gene have been described in a subset of pancreatic carcinomas. The APC gene modulates the beta-catenin-Tcf pathway. The major player in this pathway is the beta-catenin protein encoded by the beta-catenin gene. A variety of different tumors, including colon, prostate, endometrial, and hepatocellular carcinomas, carry mutations in...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 10545724
DOI: 10.1159/000007704

Genes

APC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Analysis of beta-catenin gene mutations in pancreatic tumors.PMID 10545724Read ↗

Accumulation of beta-catenin protein, mutations in exon-3 of the beta-catenin gene and a loss of heterozygosity of 5q22 in solid pseudopapillary tumor of the pancreas.Semantic proximity Read ↗

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beta-catenin gene mutation in invasive ductal breast cancer.Semantic proximity Read ↗

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Stabilization of beta-catenin induces pancreas tumor formation.Semantic proximity Read ↗

Nuclear translocation of beta-catenin protein but absence of beta-catenin and APC mutation in gastrointestinal carcinoid tumor.Semantic proximity Read ↗

Mutations of the beta- and gamma-catenin genes are uncommon in human lung, breast, kidney, cervical and ovarian carcinomas.Semantic proximity Read ↗

Accumulation of beta-catenin protein and mutations in exon 3 of beta-catenin gene in gastrointestinal carcinoid tumor.Semantic proximity Read ↗

Absence of mutations in the transforming growth factor-beta inducible early gene 1, TIEG1, in pancreatic cancer.Semantic proximity Read ↗

Mutations in beta-catenin and APC genes are uncommon in esophageal and esophagogastric junction adenocarcinomas.Semantic proximity Read ↗

Frequent somatic mutations of the APC gene in human pancreatic cancer.Semantic proximity Read ↗

Congenital pancreatoblastoma associated with β-catenin mutation.Semantic proximity Read ↗

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