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Article

Nuclear translocation of beta-catenin protein but absence of beta-catenin and APC mutation in gastrointestinal carcinoid tumor.

Annals of surgical oncology - 1 Dec 2006

Su Min-Cheng, Wang Chia-Chi, Chen Chun-Chin, Hu Rey-Heng, Wang Ting-Huang, Kao Hsin-Lien, Jeng Yung-Ming, Yuan Ray-Hwang

Abstract excerpt

BACKGROUND: Carcinoid tumors are a group of heterogeneous tumors with neuroendocrine differentiation and are mainly located in the gastrointestinal tract. A high frequency of cytoplasmic accumulation and/or nuclear translocation of beta-catenin with frequent mutations of exon 3 of beta-catenin gene in gastrointestinal carcinoid tumor has been previously described, but the role of Wnt/beta-catenin/APC pathway in...

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Identifiers

PMID: 17009161
DOI: 10.1245/s10434-006-9072-2

Genes

APC

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