Article
Absence of mutations in the transforming growth factor-beta inducible early gene 1, TIEG1, in pancreatic cancer.
Cancer letters - 26 Sept 2002
Antonello Davide, Moore Patrick S, Zamboni Giuseppe, Falconi Massimo, Scarpa Aldo
Abstract excerpt
Pancreatic cancers frequently have defects in components of the transforming growth factor-beta (TGF-beta) signaling pathway. TIEG1 (TGF-beta inducible early gene) is a recently characterized transcription factor regulated by TGF-beta that induces apoptosis when overexpressed in pancreatic adenocarcinoma cell lines. Alterations on chromosome 8q, where TIEG1 is located, are also relatively frequent in pancreatic...
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