Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The Notch locus and the genetic circuitry involved in early Drosophila neurogenesis.

Genes & development - 1 Mar 1990

Xu T, Rebay I, Fleming R J, Scottgale T N, Artavanis-Tsakonas S

Abstract excerpt

The genetic and molecular analysis of the Notch locus, which codes for a transmembrane protein sharing homology with the mammalian epidermal growth factor, suggests that the Notch protein is involved in a cell interaction mechanism essential for the differentiation of the embryonic nervous system of Drosophila. Taking advantage of the negative complementation between two Notch mutations that affect the...

Topics

Alleles
Animals
Cell Differentiation
Drosophila
Genes
Genetic Complementation Test
Membrane Proteins
Mutation
Neurons
Phenotype
Suppression, Genetic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 2338245
DOI: 10.1101/gad.4.3.464

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2338245-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The Notch locus and the genetic circuitry involved in early Drosophila neurogenesis.PMID 2338245Read ↗

Investigating the genetic circuitry of mastermind in Drosophila, a notch signal effector.Semantic proximity Read ↗

deltex, a locus interacting with the neurogenic genes, Notch, Delta and mastermind in Drosophila melanogaster.Semantic proximity Read ↗

Mastermind mutations generate a unique constellation of midline cells within the Drosophila CNS.Semantic proximity Read ↗

Transcription of the neurogenic gene mastermind during Drosophila development.Semantic proximity Read ↗

MAML1, a human homologue of Drosophila mastermind, is a transcriptional co-activator for NOTCH receptors.Semantic proximity Read ↗

New alleles of Notch draw a blueprint for multifunctionality.Semantic proximity Read ↗

Differential effects of Drosophila mastermind on asymmetric cell fate specification and neuroblast formation.Semantic proximity Read ↗

Characterization of a new mastermind allele identified from somatic mosaic screen.Semantic proximity Read ↗

Identification of chromosomal deficiencies that modify Drosophila mastermind mutant phenotypes.Semantic proximity Read ↗

Engineered truncations in the Drosophila mastermind protein disrupt Notch pathway function.Semantic proximity Read ↗

The Drosophila neurogenic locus mastermind encodes a nuclear protein unusually rich in amino acid homopolymers.Semantic proximity Read ↗

A functional analysis of Notch mutations in Drosophila.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.