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Article

The Notch locus and the genetic circuitry involved in early Drosophila neurogenesis.

Genes & development - 1 Mar 1990

Xu T, Rebay I, Fleming R J, Scottgale T N, Artavanis-Tsakonas S

Abstract excerpt

The genetic and molecular analysis of the Notch locus, which codes for a transmembrane protein sharing homology with the mammalian epidermal growth factor, suggests that the Notch protein is involved in a cell interaction mechanism essential for the differentiation of the embryonic nervous system of Drosophila. Taking advantage of the negative complementation between two Notch mutations that affect the...

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PMID: 2338245
DOI: 10.1101/gad.4.3.464

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Research trail→

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The Notch locus and the genetic circuitry involved in early Drosophila neurogenesis.PMID 2338245Read ↗

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Transcription of the neurogenic gene mastermind during Drosophila development.Semantic proximity Read ↗

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New alleles of Notch draw a blueprint for multifunctionality.Semantic proximity Read ↗

Differential effects of Drosophila mastermind on asymmetric cell fate specification and neuroblast formation.Semantic proximity Read ↗

Characterization of a new mastermind allele identified from somatic mosaic screen.Semantic proximity Read ↗

Identification of chromosomal deficiencies that modify Drosophila mastermind mutant phenotypes.Semantic proximity Read ↗

Engineered truncations in the Drosophila mastermind protein disrupt Notch pathway function.Semantic proximity Read ↗

The Drosophila neurogenic locus mastermind encodes a nuclear protein unusually rich in amino acid homopolymers.Semantic proximity Read ↗

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