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Phenotypic screening of small molecule libraries by high throughput cell imaging.

Combinatorial chemistry & high throughput screening - 1 Jun 2003

Yarrow J C, Feng Y, Perlman Z E, Kirchhausen T, Mitchison T J

Abstract excerpt

We have developed high throughput fluorescence cell imaging methods to screen chemical libraries for compounds with effects on diverse aspects of cell physiology. We describe screens for compounds that arrest cells in mitosis, that block cell migration, and that block the secretory pathway. Each of these screens yielded specific inhibitors for research use, and the mitosis screen identified Eg5 as a potential...

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PMID: 12769670
DOI: 10.2174/138620703106298527

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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