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Article

Probing cell-division phenotype space and Polo-like kinase function using small molecules.

Nature chemical biology - 1 Nov 2006

Peters Ulf, Cherian Joseph, Kim Jeffrey H, Kwok Benjamin H, Kapoor Tarun M

Abstract excerpt

Cell-permeable small molecules that inhibit their targets on fast timescales are powerful probes of cell-division mechanisms. Such inhibitors have been identified using phenotype-based screens with chemical libraries. However, the characteristics of compound libraries needed to effectively span c...

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PMID: 17028580
DOI: 10.1038/nchembio826

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-17028580-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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