Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Retargeting interleukin 13 for radioimmunodetection and radioimmunotherapy of human high-grade gliomas.

Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Oct 1999

Debinski W, Thompson J P

Abstract excerpt

A vast majority of patients with glioblastoma multiforme (GBM), a high-grade glioma, overexpress abundant amounts of a receptor for interleukin (IL)-13 in situ. This receptor is more restrictive because it is IL-4-independent and therefore differs from the IL-13/4 signaling receptor of normal tissue that is shared with IL-4. We previously identified one of the sites on the human IL (hIL)-13 molecule that is...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amino Acid Sequence
Share to Glioma

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Interleukin-13

Share to Iodine Radioisotopes

Share to Molecular Sequence Data

Share to Mutation

Source

Identifiers

PMID: 10541355

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Retargeting interleukin 13 for radioimmunodetection and radioimmunotherapy of human high-grade gliomas.PMID 10541355Read ↗

Interleukin 13 mutants of enhanced avidity toward the glioma-associated receptor, IL13Ralpha2.Semantic proximity Read ↗

A novel ligand delivery system to non-invasively visualize and therapeutically exploit the IL13Rα2 tumor-restricted biomarker.Semantic proximity Read ↗

Novel anti-brain tumor cytotoxins specific for cancer cells.Semantic proximity Read ↗

Molecular targeting of malignant gliomas with novel multiply-mutated interleukin 13-based cytotoxins.Semantic proximity Read ↗

Alanine-scanning Mutagenesis of α-Helix D Segment of Interleukin-13 Reveals New Functionally Important Residues of the CytokineSemantic proximity Read ↗

Suppression of human glioma xenografts with second-generation IL13R-specific chimeric antigen receptor-modified T cells.Semantic proximity Read ↗

Gene therapy-mediated delivery of targeted cytotoxins for glioma therapeutics.Semantic proximity Read ↗

Selective IL13Rα2-Targeted Functionality of IL13-Ligand CARs is Enhanced by Inclusion of 4-1BB Co-StimulationSemantic proximity Read ↗

In vivo DNA-launched bispecific T cell engager targeting IL-13Rα2 controls tumor growth in an animal model of glioblastoma multiformeSemantic proximity Read ↗

Molecular targeting with recombinant cytotoxins of interleukin-13 receptor alpha2-expressing glioma.Semantic proximity Read ↗

Convection-enhanced Delivery of Interleukin-13 Receptor-directed Cytotoxin for Malignant Glioma Therapy*Semantic proximity Read ↗

Interleukin-13 receptor alpha 2 cooperates with EGFRvIII signaling to promote glioblastoma multiforme.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.