Article
Gene therapy-mediated delivery of targeted cytotoxins for glioma therapeutics.
Proceedings of the National Academy of Sciences of the United States of America - 16 Nov 2010
Candolfi Marianela, Xiong Weidong, Yagiz Kader, Liu Chunyan, Muhammad A K M G, Puntel Mariana, Foulad David, Zadmehr Ali, Ahlzadeh Gabrielle E, Kroeger Kurt M, Tesarfreund Matthew, Lee Sharon, Debinski Waldemar, Sareen Dhruv, Svendsen Clive N, Rodriguez Ron, Lowenstein Pedro R, Castro Maria G
Abstract excerpt
Restricting the cytotoxicity of anticancer agents by targeting receptors exclusively expressed on tumor cells is critical when treating infiltrative brain tumors such as glioblastoma multiforme (GBM). GBMs express an IL-13 receptor (IL13Rα2) that differs from the physiological IL4R/IL13R receptor. We developed a regulatable adenoviral vector (Ad.mhIL-4.TRE.mhIL-13-PE) encoding a mutated human IL-13 fused to...
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