Article
Interleukin-13 receptor alpha 2 cooperates with EGFRvIII signaling to promote glioblastoma multiforme.
Nature communications - 4 Dec 2017
Newman Jennifer P, Wang Grace Y, Arima Kazuhiko, Guan Shou P, Waters Michael R, Cavenee Webster K, Pan Edward, Aliwarga Edita, Chong Siao T, Kok Catherine Y L, Endaya Berwini B, Habib Amyn A, Horibe Tomohisa, Ng Wai H, Ho Ivy A W, Hui Kam M, Kordula Tomasz, Lam Paula Y P
Abstract excerpt
The interleukin-13 receptor alpha2 (IL-13Rα2) is a cancer-associated receptor overexpressed in human glioblastoma multiforme (GBM). This receptor is undetectable in normal brain which makes it a highly suitable target for diagnostic and therapeutic purposes. However, the pathological role of this receptor in GBM remains to be established. Here we report that IL-13Rα2 alone induces invasiveness of human GBM cells...
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