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Article

Novel anti-brain tumor cytotoxins specific for cancer cells.

Nature biotechnology - 1 May 1998

Debinski W, Gibo D M, Obiri N I, Kealiher A, Puri R K

Abstract excerpt

The vast majority of brain cancers (gliomas) express a receptor (R) for interleukin 13 (IL13). In order to achieve specific targeting of the IL13R in gliomas, we have mutagenized human (h) IL13. The mutation was made to alter IL13 interaction with the shared functional IL13/4 normal tissue receptor, but not with the glioma-associated receptor. We have thus produced hIL13.E13K (glutamic acid at position 13 changed...

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PMID: 9592393
DOI: 10.1038/nbt0598-449

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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