Article
Analysis of HIV-1 mutation patterns in patients failing antiretroviral therapy.
Journal of clinical laboratory analysis - 1 Jan 2001
Quiros-Roldan E, Signorini S, Castelli F, Torti C, Patroni A, Airoldi M, Carosi G
Abstract excerpt
The emergence of mutations encoding drug resistance is supposed to be a significant limitation to the clinical efficacy of inhibitor compounds directed against specific HIV-1 enzymatic targets. We have used a commercial test (Visible Genetics Inc., Paris, France) to study the prevalence of mutations occurred in HIV-1 protease and reverse transcriptase (RT) genes in 93 HIV-1 infected patients treated with at least...
Topics
- Acquired Immunodeficiency Syndrome
- Antiviral Agents
- Drug Resistance, Microbial
- HIV Protease
- HIV Protease Inhibitors
- HIV-1
- Humans
- Lamivudine
- Mutation
- Nelfinavir
- RNA-Directed DNA Polymerase