Article
Temporal characterization of drug resistance associated mutations in HIV-1 protease and reverse transcriptase in patients failing antiretroviral therapy.
The new microbiologica - 1 Apr 2006
Santoro Maria Mercedes, Svicher Valentina, Gori Caterina, Zaccarelli Mauro, Tozzi Valerio, Forbici Federica, D'Arrigo Roberta, Trotta Maria Paola, Bellocchi Maria Concetta, Visco-Comandini Ubaldo, Cenci Alessandra, Bertoli Ada, Narciso Pasquale, Antinori Andrea, Perno Carlo Federico, Ceccherini-Silberstein Francesca
Abstract excerpt
The aim of this study was to evaluate the prevalence of genotypic resistance for each drug-class, and of single resistance-mutations in 1075 HIV-1 infected multi-treated patients undergoing their first genotypic resistance-test (GRT) after virological failure, over the years 1999-2003. First GRT was requested in 2003 for patients at earlier stages of failure, with less advanced disease, higher CD4-cell-count,...
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