Article
Emergence of resistance to protease inhibitor amprenavir in human immunodeficiency virus type 1-infected patients: selection of four alternative viral protease genotypes and influence of viral susceptibility to coadministered reverse transcriptase nucleoside inhibitors.
Antimicrobial agents and chemotherapy - 1 Mar 2002
Maguire Michael, Shortino Denise, Klein Astrid, Harris Wendy, Manohitharajah Varsha, Tisdale Margaret, Elston Robert, Yeo Jane, Randall Sharon, Xu Fan, Parker Hayley, May Jackie, Snowden Wendy
Abstract excerpt
Previous data have indicated that the development of resistance to amprenavir, an inhibitor of the human immunodeficiency virus type 1 protease, is associated with the substitution of valine for isoleucine at residue 50 (I50V) in the viral protease. We present further findings from retrospective genotypic and phenotypic analyses of plasma samples from protease inhibitor-naïve and nucleoside reverse transcriptase...
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