Article
Genetic variations in CC chemokine receptors and hypertension.
American journal of hypertension - 1 Jan 2006
Zhang Mingdong, Ardlie Kristin, Wacholder Sholom, Welch Robert, Chanock Stephen, O'Brien Thomas R
Abstract excerpt
BACKGROUND: CC-chemokine receptor 5 (CCR5) is a co-receptor for human immunodeficiency virus type 1 (HIV-1) infection. Homozygosity for a 32-base pair (bp) deletion (Delta32) in the CCR5 gene confers resistance to HIV-1. Previous studies found an increased prevalence of hypertension among CCR5-Delta32 homozygotes and among carriers of a polymorphism (CCR2-64I) found on the gene that codes a closely related...
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