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Article

Effects of mutations in Pneumocystis carinii dihydropteroate synthase gene on outcome of AIDS-associated P. carinii pneumonia.

Lancet (London, England) - 16 Oct 1999

Helweg-Larsen J, Benfield T L, Eugen-Olsen J, Lundgren J D, Lundgren B

Abstract excerpt

BACKGROUND: Sulpha drugs are widely used for the treatment and long-term prophylaxis of Pneumocystis carinii pneumonia (PCP) in HIV-1-infected individuals. Sulpha resistance in many microorganisms is caused by point mutations in dihydropteroate synthase (DHPS), an enzyme that is essential for folate biosynthesis. We assessed whether mutations in the DHPS gene of P. carinii were associated with exposure to sulpha...

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Share to AIDS-Related Opportunistic Infections
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Dihydropteroate Synthase

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Source

Identifiers

PMID: 10533864
DOI: 10.1016/S0140-6736(99)03320-6

Genes

DHPS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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