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Article

Dihydropteroate synthase gene mutations in Pneumocystis and sulfa resistance.

Emerging infectious diseases - 1 Oct 2004

Huang Laurence, Crothers Kristina, Atzori Chiara, Benfield Thomas, Miller Robert, Rabodonirina Meja, Helweg-Larsen Jannik

Abstract excerpt

Pneumocystis pneumonia (PCP) remains a major cause of illness and death in HIV-infected persons. Sulfa drugs, trimethoprim-sulfamethoxazole (TMP-SMX) and dapsone are mainstays of PCP treatment and prophylaxis. While prophylaxis has reduced the incidence of PCP, its use has raised concerns about development of resistant organisms. The inability to culture human Pneumocystis, Pneumocystis jirovecii, in a...

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Identifiers

PMID: 15504256
DOI: 10.3201/eid1010.030994
PMCID: PMC3323267

Genes

DHPS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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