Article
Pneumocystis carinii mutations associated with sulfa and sulfone prophylaxis failures in AIDS patients.
AIDS (London, England) - 28 May 1998
Kazanjian P, Locke A B, Hossler P A, Lane B R, Bartlett M S, Smith J W, Cannon M, Meshnick S R
Abstract excerpt
BACKGROUND: Failures of prophylaxis against Pneumocystis carinii pneumonia (PCP) in AIDS patients do occur, but no evidence for drug resistance has yet been presented. OBJECTIVE: To determine whether mutations in the sulfa and sulfone drug target are associated with failure of prophylaxis using a...
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