Pneumocystis jirovecii pneumonia in Spanish HIV-infected patients in the combined antiretroviral therapy era: prevalence of dihydropteroate synthase mutations and prognostic factors of mortality.

doi:10.1016/j.diagmicrobio.2008.04.016

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Pneumocystis jirovecii pneumonia in Spanish HIV-infected patients in the combined antiretroviral therapy era: prevalence of dihydropteroate synthase mutations and prognostic factors of mortality.

Diagnostic microbiology and infectious disease - 1 Sept 2008

Alvarez-Martínez Míriam J, Moreno Asunción, Miró José M, Valls Maria Eugenia, Rivas Paula V, de Lazzari Elisa, Sued Omar, Benito Natividad, Domingo Pere, Ribera Esteban, Santín Miguel, Sirera Guillermo, Segura Ferràn, Vidal Francesc, Rodríguez Francisco, Riera Melchor, Cordero Maria Elisa, Arribas José Ramón, Jiménez de Anta Maria Teresa, Gatell José M, Wilson Paul E, Meshnick Steven R

Abstract excerpt

The incidence of Pneumocystis jirovecii pneumonia (PCP) in HIV-infected patients has decreased thanks to sulfa prophylaxis and combined antiretroviral therapy. The influence of P. jirovecii dihydropteroate synthase (DHPS) gene mutations on survival is controversial and has not been reported in Spain. This prospective multicenter study enrolled 207 HIV-infected patients with PCP from 2000 to 2004. Molecular...

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PMID: 18554841
DOI: 10.1016/j.diagmicrobio.2008.04.016

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DHPS

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