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Article

Rapid detection of dihydropteroate polymorphism in AIDS-related Pneumocystis carinii pneumonia by restriction fragment length polymorphism.

Scandinavian journal of infectious diseases - 1 Jan 2000

Helweg-Larsen J, Eugen-Olsen J, Lundgren B

Abstract excerpt

Sulpha agents, which act by inhibiting the enzyme dihydropteroate synthase (DHPS), are used widely for the treatment and prophylaxis of Pneumocystis carinii pneumonia (PCP). Recently, we have shown that mutations in the dihydropteroate synthase (DHPS) gene of Pneumocystis carinii f.sp hominis are associated with failure of sulpha prophylaxis and increased mortality in HIV-1 positive patients with PCP, suggesting...

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Share to AIDS-Related Opportunistic Infections
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Pneumonia, Pneumocystis

Share to Polymorphism, Restriction Fragment Length

Source

Identifiers

PMID: 11055650
DOI: 10.1080/003655400458730

Genes

DHPS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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