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Article

Mutations in dihydropteroate synthase gene of Pneumocystis carinii in HIV patients with Pneumocystis carinii pneumonia.

International journal of antimicrobial agents - 1 Dec 2001

Visconti E, Ortona E, Mencarini P, Margutti P, Marinaci S, Zolfo M, Siracusano A, Tamburrini E

Abstract excerpt

The purpose of this study was to determine whether dihydropteroate synthase gene (DHPS) mutations were associated with the failure of sulpha/sulphone drugs used as prophylaxis agents in HIV infected patients. Results suggested that DHPS mutations were significantly associated with failure of anti-Pneumocystis carinii sulphone prophylaxis (P=0.031). An increasing number of mutant P. carinii strains have been...

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Source

Identifiers

PMID: 11738342
DOI: 10.1016/s0924-8579(01)00460-5

Genes

DHPS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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