Article
Dihydropteroate synthase (DHPS) gene mutation study in HIV-Infected Indian patients with Pneumocystis jirovecii pneumonia.
Journal of infection in developing countries - 24 Nov 2010
Tyagi Anuj Kumar, Mirdha Bijay Ranjan, Luthra Kalpana, Guleria Randeep, Mohan Anant, Singh Urvashi Balbir, Samantaray Jyotish Chandra, Dar Lalit, Iyer Venkateswaran K, Chaudhry Rama
Abstract excerpt
INTRODUCTION: Pneumocystis jirovecii dihydropteroate synthase (DHPS) gene mutations' (55th and 57th codon) association with prior sulfa prophylaxis failure has been reported from both developed and developing countries. We conducted a prospective study to determine the prevalence of P. jirovecii DHPS mutations from 2006 to 2009 on P. jirovecii isolates obtained from HIV-infected patients with a clinical diagnosis...
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