Article
Effect of mutations in Pneumocystis carinii dihydropteroate synthase gene on outcome of P carinii pneumonia in patients with HIV-1: a prospective study.
Lancet (London, England) - 18 Aug 2001
Navin T R, Beard C B, Huang L, del Rio C, Lee S, Pieniazek N J, Carter J L, Le T, Hightower A, Rimland D
Abstract excerpt
BACKGROUND: Investigators have reported that patients infected with Pneumocystis carinii containing mutations in the DHPS (dihydropteroate synthase) gene have a worse outcome than those infected with P carinii containing wild-type DHPS. We investigated patients with HIV-1 infection and P carinii pneumonia to determine if DHPS mutations were associated with poor outcomes in these patients. METHODS: We compared...
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