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Article

Sulfa resistance and dihydropteroate synthase mutants in recurrent Pneumocystis carinii pneumonia.

Emerging infectious diseases - 1 Jul 2003

Nahimana Aimable, Rabodonirina Meja, Helweg-Larsen Jannik, Meneau Isabelle, Francioli Patrick, Bille Jacques, Hauser Philippe M

Abstract excerpt

Failure of sulfa or sulfone prophylaxis is associated with mutations in Pneumocystis carinii gene coding for dihydropteroate synthase (DHPS). The DHPS genotype was analyzed in AIDS patients who had two separate episodes of P. carinii pneumonia. The results suggest that DHPS mutations can be selected de novo within patients by the pressure of a sulfa or sulfone drug.

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Source

Open in PubMed Open full text

Identifiers

PMID: 12890330
DOI: 10.3201/eid0907.030249
PMCID: PMC3023424

Genes

DHPS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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