Article
Genomic Imprinting: Intricacies of Epigenetic Regulation in Clusters
21 Oct 2003
Abstract excerpt
An intriguing characteristic of imprinted genes is that they often cluster in large chromosomal domains, raising the possibility that gene-specific and domain-specific mechanisms regulate imprinting. Several common features emerged from comparative analysis of four imprinted domains in mice and humans: (a) Certain genes appear to be imprinted by secondary events, possibly indicating a lack of gene-specific...
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