Article
Detection of gene mutation in skin, stomach and liver of MutaMouse following oral or topical treatment with N-methyl-N'-nitro-N-nitrosoguanidine or 1-chloromethylpyrene: some preliminary observations.
Mutagenesis - 1 Sept 1996
Brooks T M, Dean S W
Abstract excerpt
Transgenic mouse assays, such as MutaMouse, provide a method to predict the potential target organ carcinogenicity of chemical compounds. As part of a validation study, the effects of the direct-acting mutagens, N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) and 1-chloromethyl-pyrene (CMP), were investigated for gene mutation in the tissues of MutaMice after a single oral or topical exposure. MNNG (50 or 100 mg/kg)...
Topics
- Administration, Oral
- Administration, Topical
- Animals
- Cytidine Monophosphate
- Liver
- Male
- Methylnitronitrosoguanidine
- Mice
- Mice, Transgenic
- Mutagenicity Tests
- Mutagens