DNA damage and mutagenesis induced by procarbazine in lambda lacZ transgenic mice: evidence that bone marrow mutations do not arise primarily through miscoding by O6-methylguanine.

doi:10.1093/carcin/18.11.2191

Back to search

Article

DNA damage and mutagenesis induced by procarbazine in lambda lacZ transgenic mice: evidence that bone marrow mutations do not arise primarily through miscoding by O6-methylguanine.

Carcinogenesis - 1 Nov 1997

Pletsa V, Valavanis C, van Delft J H, Steenwinkel M J, Kyrtopoulos S A

Abstract excerpt

The DNA damaging and mutagenic activities of procarbazine, a methylating drug employed in cancer chemotherapy and suspected of causing therapy-related leukaemia, were investigated in the liver and bone marrow of lambda lacZ transgenic mice (MutaMouse). The drug was administered using two differen...

Topics

Animals
Antineoplastic Agents
Bone Marrow
DNA Damage
Guanine
Lac Operon
Liver
Male
Mice
Mice, Transgenic
Mutation
Procarbazine

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.