Article
Exclusion of angiotensinogen gene in molecular basis of human hypertension: sibpair linkage and association analyses in Australian anglo-caucasians.
American journal of medical genetics - 5 Nov 1999
Wang W Y, Glenn C L, Zhang W, Benjafield A V, Nyholt D R, Morris B J
Abstract excerpt
Linkage with essential hypertension has been claimed for a microsatellite marker near the angiotensinogen gene (AGT; chromosome 1q42), as has association for the AGT variants M235T, G(-6)A and A(-20)C. To more rigorously evaluate AGT as a candidate gene for hypertension we performed sibpair analysis with multiple microsatellite markers surrounding this locus and using more sophisticated analysis programs. We also...
Topics
- Adult
- Aged
- Alleles
- Angiotensinogen
- Australia
- Family Health
- Female
- Gene Frequency
- Genetic Linkage
- Genotype
- Haplotypes
- Humans
- Hypertension
- Linkage Disequilibrium