Seven Lessons From Two Candidate Genes in Human Essential Hypertension

doi:10.1161/01.hyp.33.6.1324

Article

Seven Lessons From Two Candidate Genes in Human Essential Hypertension

1 Jun 1999

Abstract excerpt

The candidate gene approach to understanding the genetics of human essential hypertension is discussed by analyzing the contribution of 2 genes, angiotensinogen (AGT) and epithelial amiloride-sensitive sodium channel (ENaC). From a large series of studies conducted in humans and animals, it appears that the AGT gene plays a significant but modest role in human blood pressure variance. Mutations of the beta- and...

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